Kardiovaskularni farmakologie novych latek

• Kardiotoxicita a predikce kardiotoxicity novych antineoplastickych latek
• Latky chelatujici zelezo - problematika jejich kardiovaskularnich a potencialne kardioprotektivnich ucinku
• Karditiotoxicita protinádorové chemoterapie a možnost farmakologické kardioprotekce - výuková prezentace s ukázkou kardiotoxických a kardioprotektivních účinků léčiv na experimentálním modelu u králíka. Prezentace ke stahnutí zde - ppt (58 MB), pdf (3 MB) - vzniklo za podpory Rozvojového programu MSMT č. 229/4/c/2006

Modelovani farmakokinetiky leciv na zaklade in vitro a in vivo experimentu

• Cytochrom P450
• Multidrug-resistance proteiny - MDR1, MRP2, BCRP
• Vliv poškození jater na exkreci léčiv

Modelování farmakokinetiky a farmakodynamiky s využitím individuálního a populačního přístupu

Bioindikátory plicních onemocnění v diagnóze a při monitorování farmakoterapie

Farmakologie oxidu dusnatého

Interaktivní programy pro výuku farmakologie

• Internet based seflevaluation clinical case studies - 2005-present - created in Macromedia Authorware
• Samostatná stránka věnovaná programu-starsi verze - 2002
• práce podpořena grantem FRVS - 2533/F3d/2002

Nase publikace

Plne texty vybranych publikací ke stazeni (pdf file):

Micuda S, Rosel D, Ryska A, Brabek J. ROCK Inhibitors as Emerging Therapeutic Candidates for Sarcomas. Curr Cancer Drug Targets. 2010 Jan 1. [Epub ahead of print]

Staud F, Ceckova M, Micuda S, Pavek P. Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics. Methods Mol Biol. 2010;596:199-222.

Cermanova J, Fuksa L, Brcakova E, Hroch M, Kucera O, Kolouchova G, Hirsova P, Malakova J, Staud F, Martinkova J, Cervinkova Z, Micuda S. Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats. Pharmacol Res. 2010 Feb;61(2):129-35.

Fuksa L, Brcakova E, Kolouchova G, Hirsova P, Hroch M, Cermanova J, Staud F, Micuda S. Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats. Toxicology. 2010 Jan 12;267(1-3):165-71.

Prochazka E, Soukup T, Hroch M, Fuksa L, Brcakova E, Cermanova J, Kolouchova G, Urban K, Mokry J, Micuda S. Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase. Int Orthop. 2010 Feb;34(1):137-42.

Steimer JL, Dahl SG, De Alwis DP, Gundert-Remy U, Karlsson MO, Martinkova J, Aarons L, Ahr HJ, Clairambault J, Freyer G, Friberg LE, Kern SE, Kopp-Schneider A, Ludwig WD, De Nicolao G, Rocchetti M, Troconiz IF. Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics. Eur J Cancer. 2010 Jan;46(1):21-32.

Popelová O, Štěrba M, Hašková P, Šimůnek T, Hroch M, Gunčová I, Nachtigal P, Adamcová M, Geršl V, Mazurová Y. Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomycytes from apoptotic cell death. Br J Cancer. 2009;101:792-802.

Simůnek T, Sterba M, Popelová O, Adamcová M, Hrdina R, Gersl V. Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol Rep. 2009 Jan-Feb;61(1):154-71.

Tuková J, Chládek J, Nemcová D, Chládková J, Dolezalová P. Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis. Clin Exp Rheumatol. 2009 Nov-Dec;27(6):1047-53.

Hroch M, Tuková J, Dolezalová P, Chládek J. An improved high-performance liquid chromatography method for quantification of methotrexate polyglutamates in red blood cells of children with juvenile idiopathic arthritis. Biopharm Drug Dispos. 2009 Apr;30(3):138-48.

Brcakova E, Fuksa L, Cermanova J, Kolouchova G, Hroch M, Hirsova P, Martinkova J, Staud F, Micuda S. Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats. Biol Pharm Bull. 2009 Dec;32(12):1978-85.

Nachtigal P, Vecerova L, Pospisilova N, Micuda S, Brcakova E, Navarro Hernandez E, Pospechova K, Semecky V. Endoglin co-expression with eNOS, SMAD2 and phosphorylated SMAD2/3 in normocholesterolemic and hypercholesterolemic mice: an immunohistochemical study. Histol Histopathol. 2009 Dec;24(12):1499-506.

Nachtigal P, Pospisilova N, Vecerova L, Micuda S, Brcakova E, Pospechova K, Semecky V. Atorvastatin Increases Endoglin, SMAD2, Phosphorylated SMAD2/3 and eNOS Expression in ApoE/LDLR Double Knockout Mice. J Atheroscler Thromb. 2009 Aug;16(3):265-74.

Pejchal J, Osterreicher J, Kassa J, Tichy A, Micuda S, Sinkorova Z, Zarybnicka L. Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells. J Appl Toxicol. 2009 May;29(4):338-45.

Cibickova L, Hyspler R, Micuda S, Cibicek N, Zivna H, Jun D, Alena T, Brcakova E, Palicka V. The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain. Steroids. 2009 Jan;74(1):13-9.

Simůnek T, Sterba M, Popelová O, Kaiserová H, Adamcová M, Hroch M, Hasková P, Ponka P, Gersl V. Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone. Br J Pharmacol. 2008 Sep;155(1):138-48.

Popelová O, Sterba M, Simůnek T, Mazurová Y, Guncová I, Hroch M, Adamcová M, Gersl V. Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo. J Pharmacol Exp Ther. 2008 Jul;326(1):259-69.

Simunek T, Sterba M, Popelova O, Kaiserova H, Potacova A, Adamcova M, Mazurova Y, Ponka P, Gersl V. Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity. Hemoglobin. 2008;32(1-2):207-15.

Chládek J, Simková M, Vanecková J, Hroch M, Chládkova J, Martínková J, Vávrová J, Beránek M. The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis. Eur J Clin Pharmacol. 2008 Apr;64(4):347-55.

Hroch M, Chladek J, Simkova M, Vaneckova J, Grim J, Martinkova J. A pilot study of pharmacokinetically guided dosing of oral methotrexate in the initial phase of psoriasis treatment. J Eur Acad Dermatol Venereol. 2008 Jan;22(1):19-24.

Chládková J, Havlínová Z, Chyba T, Krcmová I, Chládek J. Analysis of single-breath profiles of exhaled nitric oxide in children with allergy and asthma: guideline-derived plateau concentrations compared to results of automatic evaluation by two analyzers. J Asthma. 2008 Nov;45(9):820-6.

Cibicek N, Zivna H, Cibicek J, Cermakova E, Vorisek V, Malakova J, Micuda S, Palicka V. Caffeine does not modulate nutritive blood flow to rat gastric submucosa - a microdialysis study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Jun;152(1):83-90.

Fuksa L, Brcakova E, Cermanova J, Hroch M, Chladek J, Kolouchova G, Malakova J, Martinkova J, Staud F, Micuda S. Amiodarone modulates pharmacokinetics of low-dose methotrexate in rats. Biopharm Drug Dispos. 2008 Jul;29(5):289-99.

Micuda S, Brcakova E, Fuksa L, Cermanova J, Osterreicher J, Hroch M, Mokry J, Pejchal J, Martinkova J, Staud F. P-glycoprotein function and expression during obstructive cholestasis in rats. Eur J Gastroenterol Hepatol. 2008 May;20(5):404-12.

Nachtigal P, Pospisilova N, Jamborova G, Pospechova K, Solichova D, Andrys C, Zdansky P, Micuda S, Semecky V. Atorvastatin has hypolipidemic and anti-inflammatory effects in apoE/LDL receptor-double-knockout mice. Life Sci. 2008 Mar 26;82(13-14):708-17.

Micuda S, Fuksa L, Brcakova E, Osterreicher J, Cermanova J, Cibicek N, Mokry J, Staud F, Martinkova J. Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone. J Gastroenterol Hepatol. 2008 Jul;23(7 Pt 2):e225-30.

Tomsík P, Stoklasová A, Micuda S, Niang M, Suba P, Knízek J, Rezácová M. Evaluation of the antineoplastic activity of L-rhamnose in vitro. A comparison with 2-deoxyglucose. Acta Medica (Hradec Kralove). 2008;51(2):113-9.

Tomsik P, Sispera L, Rezacova M, Niang M, Stoklasova A, Cerman J, Knizek J, Brcakova E, Cermanova J, Micuda S. Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis. J Gastroenterol Hepatol. 2008 Dec;23(12):1934-40.

Chladek J, Zaludek B, Sova P. Franc A, Sispera L, Martinkova J, Micuda S, Cermanova J. Steady-state bioequivalence studies of two memantine tablet and oral solution formulations in healthy volunteers. J Appl Biomed 2008; 6(1):39-45.

Kaiserová H, Simunek T, Sterba M, den Hartog GJ, Schröterová L, Popelová O, Gersl V, Kvasnicková E, Bast A. New iron chelators in anthracycline-induced cardiotoxicity. Cardiovasc Toxicol. 2007;7(2):145-50.

Potácová A, Adamcová M, Sterba M, Popelová O, Simůnek T, Mazurová Y, Guncová I, Gersl V. A pilot study of matrix metalloproteinases on the model of daunorubicin-induced cardiomyopathy in rabbits. Acta Medica (Hradec Kralove). 2007;50(2):109-11.

Adamcová M, Simůnek T, Kaiserová H, Popelová O, Sterba M, Potácová A, Vávrová J, Maláková J, Gersl V. In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity. Toxicology. 2007 Jul 31;237(1-3):218-28.

Potácová A, Adamcová M, Cajnáková H, Hrbatová L, Sterba M, Popelová O, Simůnek T, Ponka P, Gersl V. Evaluation of ECG time intervals in a rabbit model of anthracycline-induced cardiomyopathy: a useful tool for assessment of cardioprotective agents. Physiol Res. 2007;56(2):251-4.

Sterba M, Popelová O, Simůnek T, Mazurová Y, Potácová A, Adamcová M, Guncová I, Kaiserová H, Palicka V, Ponka P, Gersl V. Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH). Toxicology. 2007 Jun 25;235(3):150-66.

Sterba M, Simůnek T, Popelová O, Potácová A, Adamcová M, Mazurová Y, Holecková M, Gersl V. Early detection of anthracycline cardiotoxicity in a rabbit model: left ventricle filling pattern versus troponin T determination. Physiol Res. 2007;56(5):535-45.

Micuda S, Fuksa L, Mundlova L, Osterreicher J, Mokry J, Cermanova J, Brcakova E, Staud F, Pokorna P, Martinkova J. Morphological and functional changes in p-glycoprotein during dexamethasone-induced hepatomegaly. Clin Exp Pharmacol Physiol. 2007 Apr;34(4):296-303.

Micuda S, Sispera L, Hodac M, Parízek P, Fuksa L, Brcáková E, Cerman J, Cermanová J, Martínková J. Diurnal variation of 6beta-hydroxycortisol in cardiac patients. Physiol Res. 2007;56(3):307-13.

Cibicková L, Palicka V, Cibicek N, Cermáková E, Micuda S, Bartosová L, Jun D. Differential effects of statins and alendronate on cholinesterases in serum and brain of rats. Physiol Res. 2007;56(6):765-70.

Celio S, Troxler H, Durka SS, Chladek J, Wildhaber JH, Sennhauser FH, Heizmann CW, Moeller A. Free 3-nitrotyrosine in exhaled breath condensates of children fails as a marker for oxidative stress in stable cystic fibrosis and asthma. Nitric Oxide. 2006 Nov;15(3):226-32.

Chladek J, Martinkova J, Vaneckova J, Grim J, Simkova M. Relationship between pharmacokinetics and therapeutic and adverse effects of methotrexate during the initial phase of treatment of moderate-severe and severe psoriasis. Klinická farmakologie a farmacie 2006;20(2):66-70. - article in Czech

Sterba M, Popelova O, Simunek T, Mazurova Y, Potacova A, Adamcova M, Kaiserova H, Ponka P, Gersl V. Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity. J Pharmacol Exp Ther. 2006 Dec;319(3):1336-47.

Adamcova M, Sterba M, Simunek T, Potacova A, Popelova O, Gersl V. Myocardial regulatory proteins and heart failure.Eur J Heart Fail. 2006 Jun;8(4):333-42.

Fuksa L, Mičuda S, Cermanová J, Brčáková E, Štaud F. Fyziologická funkce MRP2. Cs Fyziol 2006;55(2):9-16. (article in

Chladkova J, Krcmova I, Chladek J, Cap P, Micuda S, Hanzalkova Y. Validation of nitrite and nitrate measurements in exhaled breath condensate. Respiration. 2006;73(2):173-9.

Kovarikova P, Klimes J, Sterba M, Popelova O, Gersl V, Ponka P. HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;838(2):107-12.

Cibicek N, Micuda S, Chládek J, Zivný P, Zadák Z, Cermáková E, Palicka V. Lithium microdialysis and its use for monitoring of stomach and colon submucosal blood perfusion--a pilot study using ischemic preconditioning in rats. Acta Medica (Hradec Kralove). 2006;49(4):227-31.

Cibicková L, Soukup T, Cibicek N, Chládek J. Nitric oxide and systemic sclerosis. Acta Medica (Hradec Kralove). 2006;49(4):245-6.

Adamcova M, Steerba M, Simuunek T, Potaccova A, Popelova O, Mazurova Y, Gersl V. Troponin as a marker of myocardiac damage in drug-induced cardiotoxicity. Expert Opin Drug Saf. 2005 May;4(3):457-72.

Cap P, Pehal F, Chladek J, Maly M. Analysis of exhaled leukotrienes in nonasthmatic adult patients with seasonal allergic rhinitis. Allergy. 2005 Feb;60(2):171-6.

Cizkova D, Mokry J, Micuda S, Osterreicher J, Martinkova J. Expression of MRP2 and MDR1 and other hepatic markers in hepatocytes in situ and WRL 68 cells in vitro. Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):249-50.

Dolezalova P, Krijt J, Chladek J, Nemcova D, Hoza J. Adenosine and methotrexate polyglutamate concentrations in patients with juvenile arthritis. Rheumatology (Oxford). 2005 Jan;44(1):74-9.

Chladek J, Grim J, Martinkova J, Simkova M, Vaneckova J. Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis. Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):247-8.

Kovarikova P, Klimes J, Sterba M, Popelova O, Mokry M, Gersl V, Ponka P. Development of high-performance liquid chromatographic determination of salicylaldehyde isonicotinoyl hydrazone in rabbit plasma and application of this method to an in vivo study. J Sep Sci 2005;28(12):1300-6.

Micuda S, Mundlova L, Mokry J, Osterreicher J, Cermanova J, Cizkova D, Martinkova J. The effect of Mdr1 induction on the pharmacokinetics of rhodamine 123 in rats. Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):257-8.

Mičuda S, Dostál V, Martínková J. Chinolony - farmakologický přehled. Causa Subita 2005;10:383-388.

Pávek P, Červený L, Mičuda S, Štaud F, Novotná M, Fendrich Z. Nukleární receptory: xenosenzory zprostředkující odpověď organizmu na xenobiotika a příčina některých lékových interakcí. Pregnanový X nukleární receptor (PXR) a konstitutivní androstanový receptor (CAR). Remedia 2005;15(4-5):406-409.

Simunek T, Boer C, Bouwman RA, Vlasblom R, Versteilen AM, Sterba M, Gersl V, Hrdina R, Ponka P, de Lange JJ, Paulus WJ, Musters RJ. SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death. J Mol Cell Cardiol 2005;39(2):345-54.

Simunek T, Sterba M, Holeckova M, Kaplanova J, Klimtova I, Adamcova M, Gersl V, Hrdina R. Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits. Biometals. 2005 Apr;18(2):163-9.

Simunek T, Klimtova I, Kaplanova J, Sterba M, Mazurova Y, Adamcova M, Hrdina R, Gersl V, Ponka P. Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits. Pharmacol Res. 2005 Mar;51(3):223-31.

Sova P, Chladek J, Zak F, Mistr A, Kroutil A, Semerad M, Slovak Z. Pharmacokinetics and tissue distribution of platinum in rats following single and multiple oral doses of LA-12 [(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. Int J Pharm. 2005 Jan 6;288(1):123-9.

Sterba M, Simunek T, Mazurova Y, Adamcova M, Popelova O, Kaplanova J, Ponka P, Gersl V. Safety and tolerability of repeated administration of pyridoxal 2-chlorobenzoyl hydrazone in rabbits. Hum Exp Toxicol. 2005 Nov;24(11):581-9.

Cermanova J, Chladek J, Soval P, Kroutil A, Semerad M, Berankova Z, Siroky P, Surova I. Single-dose pharmacokinetics of a novel oral platinum cytostatic drug ([OC-6-43]-bis[acetato][1-adamantylamine]amminedichloroplatinum [IV]) in pigs. Methods Find Exp Clin Pharmacol 2004 Nov;26(9):679-85.

Micuda S, Mundlova L, Anzenbacherova E, Anzenbacher P, Chladek J, Fuksa L, Martinkova J. Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. Eur J Clin Pharmacol. 2004 Oct;60(8):583-9.

Cizkova D, Morky J, Micuda S, Osterreicher J, Martinkova J. Expression of MRP2 and MDR1 transporters and other hepatic markers in rat and human liver and in WRL 68 cell line. Physiol Res. 2004 Dec 09; [Epub ahead of print]

Schroterova L, Kaiserova H, Baliharova V, Velik J, Gersl V, Kvasnickova E. The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro. Physiol Res. 2004;53(6):683-91.

Cap P, Chladek J, Pehal F, Maly M, Petru V V, Barnes PJ, Montuschi P. Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients. Thorax 2004 Jun;59(6):465-470.

Simunek T, Klimtova I, Kaplanova J, Mazurova Y, Adamcova M, Sterba M, Hrdina R, Gersl V. Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents. Eur J Heart Fail. 2004 Jun;6(4):377-87.

Skalova S, Chladek J. Urinary N-acetyl-beta-D-glucosaminidase activity in healthy children. Nephrology (Carlton). 2004 Feb;9(1):19-21. pdf

Micuda S, Dostal V. Quinolones - pharmacologic overview. Causa Subita 2004;7(7) (in Czech - in press).

Martinkova J. ACE Inhibitors - pharmacologic overview. Causa Subita 2004;7(6):234-236 (in Czech).

Adamcova M, Pelouch V, Gersl V, Kaplanova J, Mazurova Y, Simunek T, Klimtova I, Hrdina R. Protein profiling in daunorubicin-induced cardiomyopathy. Gen Physiol Biophys. 2003 Sep;22(3):411-9.

Chladkova J, Chladek J, Hospodka M, Cap P: Nitric Oxide and Other Reactive Nitrogen Species: Methods and Importance for Monitoring Airway Inflammation. Alergie 2003;5(4):1-4 (in Czech) html

Safranek R, Holecek M, Kadlcikova J, Sprongl L, Mislanova C, Kukan M, Chladek J. Effect of acute acidosis on protein and amino acid metabolism in rats. Clin Nutr. 2003 Oct;22(5):437-43. pdf

Adamcova M, Sterba M, Klimtova I, Simunek T, Hrdina R, Gersl V, Ponka P. Cardiac troponins following repeated administration of an iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH)--in rabbits. Acta Medica (Hradec Kralove) 2003;46(4):171-4. (in Czech) pdf

Klimtova I, Simunek T, Mazurova Y, Kaplanova J, Sterba M, Hrdina R, Gersl V, Adamcova M, Ponka P. A study of potential toxic effects after repeated 10-week administration of a new iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits. Acta Medica (Hradec Kralove). 2003;46(4):163-70. pdf

Simunek T, Klimtova I, Adamcova M, Gersl V, Hrdina R, Sterba M, Kaplanova J, Mazurova Y. Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy. Cancer Chemother Pharmacol 2003;52(5):431-434. pdf

Micuda S, Mundlova L, Anzenbacherova E, Anzenbacher P, Chladek J, Martinkova J. Effect of memantine on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes. Proceedings of the 13^th International Conference on Cytochromes P450 (Prague, June 29-July3, 2003), Monduzzi Editore, Bologna 2003: 253-256. (ISBN 88-323-3142-X) pdf

Grim J, Chladek J, Martinkova J. Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases. Clin Pharmacokinet. 2003;42(2):139-51. pdf

Klimtova I, Simunek T, Mazurova Y, Hrdina R, Gersl V, Adamcova M. Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits. Hum Exp Toxicol. 2002 Dec;21(12):649-57. pdf

Adamcová, Michaela and Geršl, Vladimír and Macháčková, Jarmila et al. Troponins for Predicting Cardiotoxic or Cardioprotective Effects of New Drugs. In Varró, A. and Végh, Á. Advances in Recent Cardiovascular Research. Bologna: Monduzzi Editore - Medimond, 2002, p. 87 - 91. - pdf

Chladek J, Grim J, Martinkova J, Simkova M, Vaniekova J, Koudelkova V, Noiekova M. Pharmacokinetics and pharmacodynamics of low-dose methotrexate in the treatment of psoriasis. Br J Clin Pharmacol. 2002 Aug;54(2):147-56. pdf

Nobilis M, Kopecky J, Kvetina J, Chladek J, Svoboda Z, Vorisek V, Perlik F, Pour M, Kunes J. High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma. Application to a bioequivalence study in humans. J Chromatogr A. 2002 Mar 8;949(1-2):11-22. - pdf

Hrdina R, Gersl V, Klimtova I, Simunek T, Mazurova Y, Machackova J, Adamcova M. Effect of sodium 2,3-dimercaptopropane-1-sulphonate (DMPS) on chronic daunorubicin toxicity in rabbits: comparison with dexrazoxane. Acta Medica (Hradec Kralove). 2002;45(3):99-105. - pdf

Adamcova M, Machackova J, Gersl V, Pelouch V, Simunek T, Klimtova I I, Hrdina R, Ponka P. Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits. Physiol Res. 2002 Oct;51(5):443-448. - pdf

Adamcova M, Gersl V, Machackova J, Hrdina R, Klimtova I, Simunek T, Vavrova J, Bukac J. Troponins in experimental studies. Acta Medica (Hradec Kralove). 2002;45(1):29-32. - pdf

Micuda S, Grim J, Cermanova J, Martinkova J. Antibiotics. In Solutio. Prague, Medon s.r.o. 2002, 149-191, ISBN 80-902122-9-8 (in Czech).

Micuda S, Cermanova J. Aminopenicillines - pharmacologic overview. Causa Subita 3/2002:97-102 (in Czech).

Adamcova M, Machackova J, Gersl V, Hrdina R, Mazurova Y, Melka M, Nobilis M. [Plasma levels of troponin T in rabbits after administration of new antineoplastic agents (Oracin and Dimefluron) and daunorubicin] Acta Medica (Hradec Kralove) Suppl. 2001;44(1):3-8. Czech. - pdf

Chladek J, Sispera L, Martinkova J, Zaludek B, Sova P, Micuda S, Grim J, Cermanova J, Zaludek B, Sova P, Franc A. Bioequivalence of two rimantadine tablet formulations in healthy male volunteers after single dose administration. Int J Clin Pharmacol Ther. 2001 Apr;39(4):179-84. pdf

Chladek J, Martinkova J, Sispera L, Chladkova J, Cermanova J. No effect of phenobarbital pretreatment of rats on methotrexate pharmacokinetics in the isolated liver perfused in a single-pass way. Pharmacology. 2001 Feb;62(2):92-7. pdf

Machackova J, Adamcova M, Mazurova Y, Hrdina R, Nobilis M. Evaluation of cardiac effects of the new antineoplastic drug --dimethoxybenfluron--in the rabbit. Physiol Res. 2001;50(5):491-9. - pdf

Micuda S, Hodac M, Sispera L, Parizek P, Pleskot M, Zimova G, Cerman J, Martinkova J, Pidrman V. Influence of amiodarone on urinary excretion of 6beta-hydroxycortisol in humans. Physiol Res. 2001;50(2):191-6. - pdf

Martinkova et al. General pharmacology. Hradec Kralove, Olga Cermakova press 2001, 97 pages, ISBN 80-902883-4-0 (in Czech). - awarded by Czech Society of Clinical and Experimental Pharmacology and Toxicology as best publication pedagogical publication in 2001.

Micuda S, Dostal V. Makrolides - pharmacologic overview. Causa Subita 9/2001:432-434 (in Czech).

Chladek J, Sispera L, Martinkova J. High-performance liquid chromatographic assay for the determination of 5-methyltetrahydrofolate in human plasma. J Chromatogr B Biomed Sci Appl. 2000 Jul 21;744(2):307-13. - pdf

Cermanova J, Chladek J, Sispera L, Martinkova J. [Renal excretion of methotrexate in an in vivo model in minipigs] Acta Medica (Hradec Kralove) Suppl. 2000;43(2):139-47. Czech.

Chladek J, Zimova G, Beranek M, Martinkova J. In-vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4-h urine and 3-h plasma. Eur J Clin Pharmacol. 2000 Dec;56(9-10):651-7. - pdf

Hrdina R, Gersl V, Klimtova I, Simunek T, Machackova J, Adamcova M. Anthracycline-induced cardiotoxicity. Acta Medica (Hradec Kralove). 2000;43(3):75-82. Review. pdf

Machackova J, Gersl V, Adamcova M, Mazurova Y, Hrdina R, Melka M, Nobilis M. [Effects of new antineoplastic agents (dimethoxybenflurone and Oracin) on the cardiovascular system and other parameters in the rabbit in vivo] Acta Medica (Hradec Kralove) Suppl. 2000;43(2):119-38. Czech.

Micuda S, Hodac M, Parizek P, Pleskot M, Sispera L, Cerman J, Malakova J, Martinkova J, Pidrman V. Influence of CYP3A metabolizer status on the pharmacokinetics and pharmacodynamics of amiodarone. Acta Medica (Hradec Kralove). 2000;43(3):95-101.

Micuda S, Martinkova J, et al. Prescription writing. Prague, Karolinum 2000, 83 pages, ISBN 80-246-0017-X (in Czech).

Micuda S. ACE inhibitors - pharmacologic overview. Interna 2000;5:36-38 (in Czech).

Gersl V, Cerman J, Suba P, Mazurova Y, Hrdina R, Machackova J. IGF-I in experimental daunorubicin-induced cardiomyopathy in rabbits. Hum Exp Toxicol. 1999 Mar;18(3):154-61. - pdf

Gersl V, Bajgar J, Hrdina R, Mazurova Y, Machackova J, Cerman J, Suba P. Cholinesterases in dexrazoxane-treated daunorubicin cardiomyopathy in rabbits. Gen Physiol Biophys. 1999 Dec;18(4):335-46.

Machackova J, Gersl V, Hrdina R, Nobilis M, Palicka V. The influence of dimethoxybenfluron on biochemical and haematological parameters in rabbits. Acta Medica (Hradec Kralove). 1999;42(3):89-92.

Adamcova M, Gersl V, Hrdina R, Melka M, Mazurova Y, Vavrova J, Palicka V, Kokstein Z. Cardiac troponin T as a marker of myocardial damage caused by antineoplastic drugs in rabbits. J Cancer Res Clin Oncol. 1999;125(5):268-74. - pdf

Adamcová M, Gersl V, Hrdina R, Palicka V, Mazurova Y. Contribution to prediction and pathogenesis of daunorubicin-induced cardiomyopathy in rabbits. Exp Clin Cardiol 1998;3(3):179-182.

Chladek J, Zimova G, Martinkova J, Tuma I. Intra-individual variability and influence of urine collection period on dextromethorphan metabolic ratios in healthy subjects. Fundam Clin Pharmacol. 1999;13(4):508-15.

Martinkova J, Micuda S, Cermanova J, Tilser I, Chladkova J, Chladek J, Grim J, Zimova G. Direction for practical exercises in pharmacology for 3rd and 4th year students. Prague, X-Egem 1998, 84 pages, ISBN 80-7199-034-5 (in Czech) - awarded by Czech Society of Clinical and Experimental Pharmacology and Toxicology as best publication pedagogical publication in 1998.

Grim J, Micuda S, Martinkova J. Antibiotics. In Solutio. Prague, Medon s.r.o. 1999;93-135 (in Czech).

Chladkova J, Martinkova J, Chyba T. Pruduskove astma a jeho lecba v detskem veku. - Remedia. - 1999, 9, (1), s. 55-59.

Martinkova J. Leukovorin v chemoterapii nadoru. - Postgradualni medicina. - 1999, 1, (4), s. 51-55.

Chladek J, Martinkova J, Simkova M, Vaneckova J, Koudelkova V, Nozickova M. Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment. Eur J Clin Pharmacol. 1998 Feb;53(6):437-44. - pdf

Hrdina R, Gersl V, Vavrova J, Holeckova M, Palicka V, Voglova J, Mazurova Y, Bajgar J. Myocardial elements content and cardiac function after repeated i.v. administration of DMPS in rabbits. Hum Exp Toxicol. 1998 Apr;17(4):221-4. - pdf

Micuda S, Martinkova J, Chladek J, Anzenbacher P. Importance of polymorphism in drug metabolism for recent pharmacotherapy. Remedia 1998;8:98-108 (in Czech).

Micuda S, Martinkova J. Therapeutic potential of amiodarone. Prakt Lék 1998;78:53-59 (in Czech).

Martinkova J., Chladkova J., Parakova Z.: Generalizovane krece u astmaticky. Remedia 8(2), str. 115-118, 1998.

Martinkova J., Chladkova J.: Lekova zavislost. Solutio. Prirucni kniha pro lekarny. 1998, str. 153-168.

Martinkova J. Chladkova J., Chladek J.: Akutni tonzilofaryngitida a její lecba. Remedia 8(5), str. 309 - 312, 1998.

Suchankova J, Gersl V, Fiala Z, Mazurova Y, Palicka V, Vavrova J, Voglova J, Visnovsky P. The effects of subchronical exposure to SO2 on biochemical and hematological parameters in guinea pigs. Acta Medica (Hradec Kralove). 1997;40(4):95-7.

Gersl V, Hrdina R, Vavrova J, Holeckova M, Palicka V, Voglova J, Mazurova Y, Bajgar J. Effects of repeated administration of dithiol chelating agent--sodium 2,3-dimercapto-1-propanesulphonate (DMPS)--on biochemical and haematological parameters in rabbits. Acta Medica (Hradec Kralove). 1997;40(1):3-8.

Chladek J, Martinkova J, Sispera L. An in vitro study on methotrexate hydroxylation in rat and human liver. Physiol Res. 1997;46(5):371-9.

Chladkova J., Martinkova J., Pokorna E., Obrsalova S., Buriankova B.: Systemova kandidoza u nedonoseného novorozence. Remedia 7(3), 1997, str. 195-199.

Martinkova J., Chladkova J.: Katetrova bakteriemie u ditete s akutni lymfoblastickou leukemii. Remedia 7(1): 1997, 45-48.

Micuda S, Martinkova J. Management of insomnia. In Solutio. Prague, Medon s.r.o. 1997;21-25 (in Czech).

Martinkova J.: Astma a jeho lecba. Solutio. Prirucni kniha pro lekarny. Medon s.r.o., 1997: 13-19.

Cermanova J., Martinkova J., Cerman J.: Zvraceni. Prirucni kniha pro lekarny. Medon s.r.o., 1997: 26-30.

Gersl V, Bajgar J, Krs O, Hrdina R, Palicka V, Mazurova Y. Changes in cholinesterase activities after daunorubicin administration to rabbits. Hum Exp Toxicol. 1996 Oct;15(10):834-8.

Hrdina R, Gersl V, Svoboda D. Acute haemodynamic effects of diltiazem and its distribution in relation to the myocardial infarction size. Acta Medica (Hradec Kralove). 1996;39(3):107-13.

Vachek J, Gersl V, Fusek J, Krs O, Skopec F, Bajgar J. Toxicities of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates (V-compounds). Acta Medica (Hradec Kralove). 1996;39(2):67-71.

Gersl V, Mazurova Y, Bajgar J, Melka M, Hrdina R, Palicka V. Lack of cardiotoxicity of a new antineoplastic agent, a synthetic derivative of indenoisochinoline: comparison with daunorubicin in rabbits. Arch Toxicol. 1996;70(10):645-51.

Chladkova J., Martinkova J., Hak J., Slavík Z.: Plicni kandidoza pri febrilni neutropenii. Modelova studie. Remedia 6 č. 1, 1996, str. 82-86.

Smahelova A., Martinkova J., Vodicková L.: Diabeticka noha. Modelova studie. Remedia 6, č. 2-3, 1996, str. 169-174.

Chladkova J., Chladek J., Hak J., Slavik Z., Martinkova J.: Ofloxacin versus Co-Trimoxazole in Prevention of Infections in Children with Neutropenia after Cytotoxic Chemotherapy. Antiinfect Drug Chemother 12(2), 1996, str. 105-107.

Chladkova J., Martinkova J.: Febrilni neutropenie a jeji antibioticka lecba. Remedia 6 (č. 6), 361-365, 1996.

Simkova M., Vaneckova J., Koudelkova V., Nozickova M., Chladek J., Martinkova J.: Metotrexat a jeho vyuziti v lecbe psoriazy. Cs. dermatologie, 71, č. 4, 1996, str. 171-175.