Mazanek, Pavel
Poslední změna: 18.06. 2020

Research

Academic staff of the Department of Pharmacology is currently grouped into three tightly co-operating research groups:

Cardiovascular pharmacology (CardioTox)

Head: Assoc. Prof. Martin Sterba, PharmD., PhD.
 
We study cardiovascular toxicity of antineoplastic drugs with the potential of pharmacologic cardioprotection. While in the past we have focused on clinically significant cardiotoxicity of anthracycline antineoplastics (for example, doxorubicin or daunorubicin), recently we have chosen to investigate specific biologically-aimed drugs (for example, Sunitinib or inhibitors of proteasome). We are focusing mainly on in vivo research into the chronic forms of cardiovascular toxicity of these abovementioned drugs in laboratory animals (rabbits, rats and mice).

Liver pharmacology (LivPharm)

Head: Prof. Stanislav Micuda, MD, PhD

Main research focus is the evaluation of factors responsible for variability in hepatic drug excretion with special attention paid to drug-drug and drug-food/natural product interactions. Associated topic is the study of the physiology and pathology of bile formation, and consequent therapeutic possibilities for nonalcoholic fatty liver disease, and various cholestatic liver diseases including those produced by various xenobiotics.

Clinical pharmacology

Head: Assoc. Prof. Jaroslav Chladek, MSc., PhD.

We focus on the usage of individual and population modelling of pharmacokinetics, pharmacodynamics, and bio-indicators of therapeutic and toxic effects of drugs for individualization in pharmacotherapy. In the field of clinical pharmacology, we have been cooperating for 15 years with the Department of Dermatology and Venereology at the University Hospital Hradec Králové on the topic of methotrexate in curing focal psoriasis. Other areas of clinical pharmacology research are the treatment of idiopathic juvenile arthritis, Crohn’s disease, and the usage of non-invasive methods of examining bioindicators in respiratory tract disease with inflammation.



 

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