Kucera, Otto
Poslední změna: 12.12. 2013

Nejvýznamnější publikace za dobu působení skupiny

  1. Holeček M., Skopec F., Šprongl L., Pecka M. Protein metabolism in specific tissues of endotoxin-treated rats: effect of nutritional status. Physiol. Res. 44: 339-406, 1995.
  2. Holeček M., Skopec F., Šprongl L. Protein metabolism in cirrhotic rats: effect of dietary restriction. Ann. Nutr. Metab. 39: 346-354, 1995.
  3. Holeček M., Tilšer I., Skopec F., Šprongl L. Leucine metabolism in cirrhotic rats. J. Hepatol. 24: 209-216, 1996.
  4. Holeček M. Leucine metabolism in fasted and TNF treated rats. Clin. Nutr. 15: 91-93, 1996.
  5. Holeček M., Mráz J., Tilšer I. Plasma amino acids in four models of experimental liver injury in rats. Amino Acids 10: 229-241, 1996.
  6. Tilšer I., Tichý M., Ettlerová E., Holeček M. Effect of supplementation of modified UW solution with OKY-460 on long-lasting hypothermic liver storage of rats. Cryo-Lett. 17: 371-378, 1996.
  7. Holeček M., Tilšer I., Skopec F., Šprongl L. Leucine metabolism in partially hepatectomized rats. J. Hepatol. 26: 1141-1147, 1997.
  8. Holeček M., Šprongl L., Skopec F., Andrýs C., Pecka M. Leucine metabolism in TNF-a- and endotoxin-treated rats: contribution of hepatic tissue. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E1052-1058, 1997.
  9. Holeček M., Šprongl L., Tichý M., Pecka M. Leucine metabolism in rat liver after a bolus injection of endotoxin. Metabolism 47: 681-685, 1998.
  10. Holeček M., Skalská H., Mráz J. Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose-response and time-response study in rats. Amino Acids 16: 1-11, 1999.
  11. Holeček M. Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: a review. Nutrition 15: 784 -788, 1999.
  12. Holeček M., Skopec F., Skalská H., Šprongl L. Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats. JPEN J. Parent. Ent. Nutr. 24: 215-222, 2000.
  13. Holeček M., Šprongl L. Tichý M. Effect of hyperammonemia on leucine and protein metabolism in rats. Metabolism 49: 1330-1334, 2000.
  14. Teplan V., Schück O., Horáčková M., Skibová J., Holeček M. Effect of a keto acid-amino acid supplement on the metabolism and renal elimination of branched-chain amino acids in patients with chronic renal insufficiency on a low protein diet. Wien Klin. Wochenschr. 112: 876-881, 2000.
  15. Holeček M., Skopec F., Šprongl L. Influence of buthionine sulfoximine, S-adenosylmethionine and glutathione on liver regeneration following partial hepatectomy. Arzneim. Forsch. Drug Res. 50: 1093-1098, 2000.
  16. Holeček M., Šprongl L., Tilšer I., Tichý M. Leucine and protein metabolism after bilateral nephrectomy in rats: the role of hepatic tissue. Res. Exp. Med. 200: 53-65, 2000.
  17. Holeček M. The BCAA-BCKA cycle: Its relation to alanine and glutamine synthesis and protein balance. Nutrition 17: 70, 2001.
  18. Holeček M. Effect of starvation on branched-chain a-keto acid dehydrogenase activity in rat heart and skeletal muscle. Physiol. Res. 5: 19-24, 2001.
  19. Holeček M., Šprongl L., Tilšer I. Metabolism of branched-chain amino acids in starved rats. The role of hepatic tissue. Physiol. Res. 50: 25-33, 2001.
  20. Holecek M., Sprongl L., Tilser I., Tichy M. Leucine and protein metabolism in rats with chronic renal insufficiency. Exp. Toxicol. Pathol. 53:71-6, 2001.
  21. Holeček M., Skopec F., Šprongl L Mráz J. Skalská H., Pecka M. Effect of alanyl-glutamine on leucine and protein metabolism in irradiated rats. Amino Acids 22: 98-1058, 2002.
  22. Holeček M. Relation between glutamine, branched-chain amino acids, and proten metabolism. Nutrition 18:130-133, 2002.
  23. Šafránek R., Holeček M., Kadlčíková J., Šprongl L., Mislanová C., Kukan M., Chládek J. Effect of acute acidosis on protein and amino acid metabolism in rats. Clin. Nutr. 22: 437-443, 2003.
  24. Holeček M., Ryšavá R., Šafránek R., Kadlčíková J., Šprongl L. Acute effects of decreased glutamine supply on protein and amino acid metabolism in hepatic tissue. A study using isolated perfused rat liver. Metabolism 52: 1062-7, 2003.
  25. Holeček M., Šafránek R., Ryšavá R., Kadlčíková J., Šprongl L. Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver. Int. J. Exp. Pathol. 84: 185-190, 2003.
  26. Holeček M., Bielavská M., Šprongl L Protein metabolism in guanethidine treated rats. Int. J. Exp. Pathol. 85: 257-264, 2004.
  27. Kadlčíková J., Holeček M., Šafránek R., Tilšer I., Kessler B. M. Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats. Int. J. Exp. Pathol. 85: 365-371, 2004.
  28. Holeček M. Contribution of amino acids to ketogenesis. In: Amino Acid Metabolism and Therapy in Health and Nutritional Disease, Ed. Luc A. Cynober, CRC Press, 2004, s. 97-110.
  29. Kadlčíková J., Holeček M., Šafránek R., Tilšer I. Direct effects of proteasome inhibitor AdaAhx3L3VS on protein and amino acid metabolism in rat skeletal muscle. Physiol. Res. 54: 541-547, 2005.
  30. Šafránek R., Holeček M., Šišpera L., Muthný T. Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis. Ann. Nutr. Metab. 50(4): 361-7, 2006.
  31. Holeček M. , Muthný T., Kovařík M., Šišpera L. Proteasome inhibitor MG-132 enhances whole-body protein turnover in rat. Biochem. Biophys. Res. Commun. 345: 38-42, 2006.
  32. Šafránek R., Ishibashi N., Oka Y., Ozasa H., Shirouzu K., Holeček M. Modulation of inflammatory response in sepsis by proteasome inhibition. Int. J. Exp. Pathol. 87: 369-372, 2006.
  33. Holeček M., Muthný T., Kovařík M., Šišpera L. Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions. JPEN J. Parent. Ent. Nutr. 30 (6):467-473, 2006.
  34. Tisančinová J., Holeček M., Tilšer I. Obrana proti buněčnému „polibku smrti“. Vesmír 86: 383-384, 2007.
  35. Muthný T., Kovařík M., Šišpera L., Tilšer I., Holeček M. Protein metabolism in slow- and fast-twich muscle during turpentine-induce inflammation. Int. J. Exp. Pathol. 89: 64-71, 2008.
  36. Holeček M., Muthný T., Kovařík, Šišpera L. Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues. Food. Chem. Toxicol. 47: 255-259, 2009.
  37. Muthný T., Kovařík M., Šišpera L., de Meijere A., Larionov O. V., Tilšer I., Holeček M. The effect of new proteasome inhibitors, belactosin A and C, on protein metabolism in isolated rat skeletal muscle. J. Physiol. Biochem. 65:137-146, 2009.
  38. Holeček M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition 26:482-490, 2010.
  39. Kovařík M., Muthný T., Sispera L., Holecek M. Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats. J. Physiol. Biochem. 66: 311-319, 2010.
  40. Holeček M., Kanďár R., Šišpera L., Kovařík M. Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle. Amino Acids 40: 575-584, 2011.
  41. Holeček M. Branched-chain amino acid oxidation in skeletal muscle – physiological and clinical importance of its modulation by reactant availability. Curr. Nutr. Food Sci. 7: 50 – 56, 2011.
  42. Holecek M., Kovarik M. Alterations in protein metabolism and amino acid concentrations  in rats fed by a high-protein (casein-enriched) diet -  Effect of starvation.  Food Chem. Toxicol. 49:3336-3342, 2011
  43. Kovarik M., Muthny T., Sispera L., Holecek M. The dose-dependent effects of endotoxin  on protein metabolism in two types of rat skeletal muscle.  J. Physiol. Biochem. 68:385-395,2012
  44. Holecek M. Muscle wasting in animals models of severe illness. Int. J. exp. Pathol. 93: 157-71, 2012
  45. Holecek M. Side effects of long-term glutamine suplementation. JPEN J Parenetr Enteral Nutr. 37: 607-616, 2013
  46. Holecek M. Branched-chain amino acids and ammonia metabolism in liver disease: therapeutic implications. Nutrition 29: 1186-1191, 2013
  47. Holecek M. Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy – therapeutic perspectives. Metab Brain Dis  (in press)

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