Achievements












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            * Publications
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            Cahlíková, L., Kawano, I., Řezáčová, M., Blunden G, Hulcová D, Havelek R: 

            TheAmaryllidaceaealkaloidshaemanthamine, haemanthidine and theirsemisyntheticderivatives a
            PhytochemRev. 2021; 20: 303–323. https://doi.org/10.1007/s11101-020-09675-8 IF 7,7 
            Koutova D, Maafi N, Muthna D, Kralovec K, Kroustkova J, Pidany F, Timbilla AA, Cermakova E

            L, Rezacova M, Havelek R. Antiproliferativeactivity and apoptosis-inducingmechanismofAmary
            alkaloid montanine on A549 and MOLT-4 humancancercells. BiomedPharmacother. 2023;166:11529
            j.biopha.2023.115295. IF 7,5 

             
            Gorecki L, Muthna D, Merdita S, Andrs M, Kucera T, Havelek R, Muckova L, Kobrlova T, Souku

            P, Prchal L, Soukup O, Roh J, Rezacova M, Korabecny J: 7-Azaindole, 2,7-diazaindole, and 1
            as corestructuresfor novel anticanceragentswithpotentialchemosensitizingproperties.?Eur J 
            2022;240:114580. doi: 10.1016/j.ejmech.2022.114580?IF 6,7 

             
            An alternativeapproach to validationofliquidchromatography-
            massspectrometrymethodsforthequantificationofendogenouscompounds. Uher M., Mičuda S., Kace

            M. J. Chromatogr. A, 2023, 30:1705:464173. IF = 4.6 
             
            Mrkvicová A, Peterová E, Nemec I, Křikavová R, Muthná D, Havelek R, Kazimírová P, Řezáčová

            P: Rh(III) and Ru(II) complexeswithphosphanyl-alkylamines: inhibitionof DNA synthesisinduc
            anticancerRhcomplex. Future Med Chem. 2023. doi: 10.4155/fmc-2023-0170 IF 4,2 
             

            Masaryk L, Muthná D, Halaš P, Zoufalý P, Peterová E, Havelek R, Drahoš B, Milde D, Mrkvico
            P.: Stability of a half-sandwichOs(II) complexwithindomethacin-functionalized ligand in th
            ofcarboxypeptidase A.  Dalton Trans. 2022;51(24):9213-9217. doi: 10.1039/d2dt01085b IF 4,0

             
            High-throughputsalting-out assistedliquid-liquidextractionusing a 3Dprinteddevice and itsa
            thequantificationofibrutinib and its metabolite PCI-45227 in humanserum. 

            Écsiová D, Šimkovič M, Uher M, Hroch M. J Pharm BiomedAnal. 2022; 219:114923. IF = 3.6 





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            * Patents
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            Anticancer compounds based on nitrogen heterocycles, their use as drugs and pharmaceutical

            containing them. Czech patent deed (patent file), patent number 309579. Issued on 15.3.202
            1-aryloxy-3-(4-(2-hydroxyethyl)piperazin-1-yl)propan-2-ols, method of their preparation an
            Czech patent deed (patent file), patent number 309081. Issued on 14.1.2022.






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            * Others

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            DSP Medical Chemistry and Biochemistry student Mgr. Darja Koutová, Ph.D. (supervisor doc. 
            Mayor of Hradec Králové Award for student creative work in 2020.

            DSP Medical Chemistry and Biochemistry student Mgr. Darja Koutová, Ph.D. (supervisor doc. 
            the 1st prize at the DSP LF UK HK student conference in 2021.