Department of Physiology












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            Scientific research work together with teaching activities and activities related to the r

            faculty are the three basic pillars of the work activities of the staff of the Institute o
            Academic staff of the Institute annually publish the results of their scientific research 
            in renowned impacted journals and present them at professional national and international 

            In addition to solving a number of their own grant projects, employees of the Institute of
            participate in the review process of national and international grants and scientific publ
            international renowned journals. Academic staff of the Institute also participate in the p

            of scientific monographs. The scientific research activities of the Institute of Physiolog
            focused mainly on experimental hepatology and mitochondrial physiology (non-alcoholic fatt

            experimental cardiology (cardiotoxicity of antineoplastic agents) and the study of protein
            metabolism in health and disease.






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            * Main research topics
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            • Metabolism and bioenergetics - study of non-alcoholic fatty liver disease (NAFLD) with e
              bioenergetic aspects; nutritional and pharmacological influences on the development of N
              reversal of more advanced forms of NAFLD; use of ketodiet in the treatment of hereditary

              disorders; disorders of lipid and carbohydrate metabolism in obstructive sleep apnea syn
            • Cardiotoxicity of antineoplastic agents; study of myocardial remodeling in various patho
              conditions

            • Protein and amino acid metabolism in health and disease, prof. Holeček [ URL "https://is
              webapps/whois2/osoba/1298879788900355/?lang=cs"]







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            * Scientific research groups

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            • Experimental Hepatology and Mitochondrial Physiology Group
            • Experimental Cardiology Group

            • Group Protein and Amino Acid Metabolism in Health and Disease





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            * Achievements
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            • Organization of the international conference MiP 2017 "12th Conference on Mitochondrial 

              role of mitochondria in lifestyle and metabolic syndrome - COST MitoEAGLE perspectives a
              and MC Meeting" in Hradec Králové in 2017.
            • Invited lectures at International Council on Amino Acids, Tokyo, 2018 (prof. Holeček); S

              Sarcopenia, Cachexia and Wasting Disorders, Lisbon, 2022 (prof. Holeček [ URL "https://i
              webapps/whois2/osoba/1298879788900355/?lang=cs"] ).
            • Professional monograph by prof. Holecek "Amino acids - physiology, pathophysiology and a

              supplement", GRADA (February 2023); chapters in professional monograph "Hepatology", GRA
              Červinková, doc. Kučera, dr. Šafka).


            Czech Hepatological Society of the Czech Academy of Sciences for the best published work i
            of hepatology (2009, 2013, 2015, 2017 and 2020). Award of the Czech Physiological Society 
            Academy of Sciences for the best scientific paper (2015). Awards of the Czech Society of H

            JEP for the best poster (2006, 2013, 2014, 2015 and 2022) and lecture (2009, 2010) at the 
            Days. Elucidation of the pathogenesis of the increase of branched chain amino acids (valin
            isoleucine) in diabetes and their decrease in liver cirrhosis (Prof. Holecek).