Department of Histology and Embryology












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            The Department of Histology and Embryology is dedicated to the investigation of the micros

            of tissues, organs and cells at the level of light microscopy and ultrastructure. It combi
            with the identification of key tissue and cellular molecules in the analysis of intact, de
            regenerating, or aging cells and tissues, which are often affected by external factors or 

            transfers his knowledge and expertise to undergraduate and postgraduate students, applies 
            own research activities and translates it into numerous collaborations at various levels o
            research. The Institute includes Histology Laboratories for tissue sample processing, Immu

            Laboratory, Fluorescence Microscopy Laboratory, Transmission Electron Microscopy, Molecula
            Laboratory and Stem Cell Culture Laboratories.






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            * Main research topics

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            • Research on stem cells - their cultivation, differentiation, new methods of cryopreserva
              analysis of their behaviour in different environments and on different carriers, includi

              carriers.
            • Study of the ultrastructure of cells and tissues in vitro and in situ
            • Testing the effect of antibiotics and chemotherapeutics on stem cells, development of ne

              drugs.





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            * Achievements
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            • D1 publikace: Aagenaesův syndrom/lymfedémová cholestáza 1 je způsoben zakladatelskou var

              nepřekládané oblasti UNC45A. J Hepatol. 2023;79(4):945-954; IF 25,7
            • Harrison SP et al. Scalable production of tissue-like vascularized liver organoids from 
              (Škálovatelná produkce tkáni podobných vaskularizovaných jaterních organoidů z lidských 

              Med. 2023 Sep;55(9):2005-2024; IF 12,8
            • Wesseler MF et al. 3D mikroperfuze lidských mikrofyziologických modelů jater v mezoměřít
              funkčnost a rekapituluje jaterní zonálnost. Acta Biomaterialia, 171, 336-349; IF 10,633






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            * Equipment

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            • JEOL JEM1400Plus transmission electron microscope equipped with EDS (for elemental compo
              and cryo accessories

            • Smart Zoom / Patho Zoom + AI Image Analysis
            • Ultramicrotome PowerTome from RMC Boeckeler