Department of Preventive Medicine ****************************************************************************************** * ****************************************************************************************** The Institute of Preventive Medicine was established on 1st January 2021 following the res the Institute of Hygiene and Preventive Medicine and the Institute of Social Medicine. The Institute is still Prof. MUDr. Lenka Borská, Ph.D. The teaching and research focus of the to the fields of hygiene, epidemiology, toxicology, public health, practical medicine, psy medical ethics. The Institute provides teaching in six undergraduate study programmes (38 guarantees two internships and one state rigorous examination from Preventive Medicine. Th training centre for two doctoral study programmes (Preventive Medicine and Public Health) in specialisation training of doctors (attestations) in the field of Hygiene and Epidemiol the field of prevention and toxicology is oriented (1) on the study of the organism's resp to selected chemical factors (nanoparticles and nanomaterials), (2) on the study of preven pathophysiological mechanisms of the origin and development of selected civilization disea metabolic syndrome, diabetes mellitus, cancer, psoriasis vulgaris) and (3) on the evaluati of aging. Research in the field of epidemiology is oriented in the areas of clinical epide epidemiology of non-communicable diseases, pharmacoepidemiology, medical statistics, and i of strategy for planning clinical trials of new vaccines. Research in the fields of public general practice is oriented towards optimisation of the network of GP providers in the Cz legislative modifications of their competences. Research in the areas of psychosocial and focused on the assessment of the quality of life of patients ("Well-being"), medical ethic diseases, and the issue of doctor-patient communication. Domestic cooperation: University Hospital Hradec Králové, Military Medical Faculty of the of Defence, Faculty of Chemical Technology of the University of Pardubice and Centre of Ma Nanotechnologies (CEMNAT), The Society of General Practice. International cooperation: Epigenetic Clock Development Foundation (Torrance, California, HealthyLongevity.clinic Inc. (Boca Raton, Florida, USA); Glycanage Ltd. (Newcastle Upon Ty Trudiagnostic (Lexington, Kentucky, USA); Department of Humanities, University of Naples F (Naples, Italy); SUNY Upstate Medical University (New York, USA); Johns Hopkins Bloomberg Health (Maryland, USA); Trinity Translational Medicine Institute, School of Medicine (Trin Dublin, Ireland). Currently, the research activities of the Institute are financially supported by projects AZV (NU23J-07-00018), COOPERATIO (UK Programme), WELLBEING project (no. 22310140), Erasmus project. ****************************************************************************************** * Main research topics ****************************************************************************************** • Study of preventable immuno-pathophysiological mechanisms of civilisation diseases and b aging • Study of the toxicity of nanomaterials • Assessment of quality of life ****************************************************************************************** * Equipment ****************************************************************************************** • Automated Metafer system (Comet assay, chromosomal aberrations) • Fluorescence microscope (Comet assay) • Cell culture laboratory ****************************************************************************************** * Achievements ****************************************************************************************** • Publications of monographs: (1) MAREŠ, Jiří. Health psychology. (2) FIALA, Zdeněk and Dr HOLMANNOVÁ. Carbon nanomaterials. Biomedical applications and toxicity. Karolinum, 2024 • 2020: Prof. MUDr. Roman Prymula, CSc., Ph.D. was awarded the Order of the White Lion 1st division • 2023: Prof. MUDr. Lenka Borská, Ph.D. and Prof. Ing. Zdeněk Fiala, CSc. were included wi biographies in the Encyclopedia of Personalities of the Czech and Slovak Republic, XI. e 978-1-912100-06-4) • "Become a practitioner in the Hradec Králové Region!" (2022-2023, project coordinator: K Javorská, MD) • "Know the Power of Prevention" (2024, guarantor: prof. MUDr. Lenka Borská, Ph.D.): the f prevention and awareness-raising event for the general public organized by students unde of the Institute of Preventive Medicine of the Faculty of Medicine ****************************************************************************************** * Publication ****************************************************************************************** • Borsky, P., Fiala, Z., Andrys, C., Beranek, M., Hamakova, K., Malkova, A., ... & Rehacek Alarmins HMGB1, IL-33, S100A7, and S100A12 in psoriasis vulgaris. Mediators of inflammat • Holmannova, D., Borska, L., Andrys, C., Borsky, P., Kremlacek, J., Hamakova, K., ... & F The impact of psoriasis and metabolic syndrome on the systemic inflammation and oxidativ nucleic acids. Journal of immunology research, 2020. • Karas, A., Holmannova, D., Borsky, P., Fiala, Z., Andrys, C., Hamakova, K., ... & Borska Significantly altered serum levels of NAD, AGE, RAGE, CRP, and elastin as potential biom psoriasis and aging—a case-control study. Biomedicines, 10(5), 1133. • Borsky, P., Holmannova, D., Andrys, C., Kremlacek, J., Fiala, Z., Parova, H., ... & Bors Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11 NAD+, NLRP3, DNA/RNA damage, and klotho. Biogerontology, 24(6), 937-955. • Holmannova, D., Borsky, P., Parova, H., Stverakova, T., Vosmik, M., Hruska, L., ... & Bo Non-genomic hallmarks of aging—The Review. International Journal of Molecular Sciences,  • Schettino, G., Hodačová, L., Caso, D., & Capone, V. (2024). Physicians’ adoption of mass courses content in the workplace: An investigation on the training transfer process thro of planned behavior. Computers in Human Behavior, 154, 108151.