Department of Pharmacology












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            The members of the Department are continuously working on the maintenance of highest possi

            teaching strategies and research achievements within the Pharmacology keeping up with curr
            on evidence-based approaches.
            We have gradually created and continuously upgrade study texts available to our students a

            of our department, and have introduced three supporting computer applications. The first s
            were interactive presentations purchased from the companies Pharmac-a-logy and Pharmatutor
            students illustrative presentations of indivi dual problems in the field. This has been cl

            with the usage of computer simulations which have gradually replaced demanding experiments
            or on isolated organs and help demonstrate the mechanisms of the effect of the chosen drug

            pharmacokinetics. The third supporting application are case reports from clinical practice
            prepared in cooperation with specialists from individual clinics and presented in the form
            web applications describing solutions to specific pharmaco-therapeutic situations. All the

            materials are at present available on our faculty´s secure server – moodle.lfhk.cuni.cz.





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            * Main research topics
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            • Cardiovascular toxicity of anticancer drugs and pharmacological cardioprotection in vivo

            • Hepatic effects of existing or newly developed drugs.
            • Modelling pharmacodynamics and pharmacokinetics of drugs in clinical practice.




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            * Equipment
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            Management and introduction into research of the device located in the central laboratory 

            LFHK: High-frequency ultrasound device for examination of small laboratory animals VEVO310
            VisualSonics, Canada) with accessories. Use for experimental research of cardiotoxicity in
            Štěrba) and cooperation with doc. Kacerovská (Gyn-Por Clinic) and the use of the device to

            effect of intra-amnion inflammation and drugs on the rat fetus




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            * Achievements

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            • D1 publications with other authors from our department (co-corresponding author doc. Ště
              et al. Circulation-Heart Failure 2021;14:e008209, IF 10,447, AIS 4,101

            • D1 publications (corresponding author doc. Chládek): Parizkova RC et al. Critical Care 2
              IF 19.3, AIS 3.95


            J Roh, M. Štěrba et al. International patent WO2021/144746 A1 (PCT/IB2021/050285). M. Štěr
            Editor in ESC Heart Failure (2017-present, IF 4.411, Wiley, Journal of European Society of
            Cardiovascular Toxicology (2018-2022, IF 3.239, Springer), M. Štěrba was awarded the Arnos

            Prize by the Rector of Charles University in 2019 as a member of the author collective. DS
            Pharmacology student Mgr. Petra Kollárová (supervisor doc. Štěrba) won the 1st prize at th
            UK student conference in 2021. The same prize was won in 2018 by Mgr. Alena Prašnická (sup

            Mičuda). Award of the CSCEFT CSL JEP for the best publication (4 times since 2018).