Department of Pathological Physiology












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            The scientific activity of the Institute of Pathological Physiology is electrophysiologica

            visual perception and brain functions and its possible diagnostic applications. Our main f
            ophthalmology, but we also work closely with other clinical departments such as infectious
            psychiatry and paediatric clinics. Our activities take place in the Electrophysiology Labo

            founded in the 1970s by Prof. J. Peregrine and Prof. J. Svěrák and which has been a joint 
            Institute of Pathological Physiology and the Institute of Medical Biophysics since 1 Octob
            probably the most important laboratory of its kind in the Czech Republic and the only Czec

            in the International Society for Clinical Electrophysiology of Vision (ISCEV). Our laborat
            of priority results in the field of research on motion evoked potentials and visual "misma

            and their practical application. We are currently testing a mobile device we have develope
            testing and are pursuing its commercial use (https://www.veppeak.com/). The instrumentatio
            combine functional (VEP, ERP, EEG) and morphological approaches (refractometry, OCT) in th

            investigation.

            The investigation of a wide range of VEPs and cognitive potentials, which exceeds the inte

            standards set by the ISCEV recommendation and significantly increases its sensitivity, can
            a specific activity of the pathophysiological part of the laboratory. These activities als
            relatively high citation rate of our publications.






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            * Main research topics

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            • Analysis of VEP non-stationarity as a new potential diagnostic criterion
            • Application of the VEPpeak mobile device for the objectification of cognitive changes in

              diseases (e.g. schizophrenia)
            • Distance visual rehabilitation of visually impaired elderly with macular degeneration






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            * Scientific research groups
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            The core scientific research team consists of all university and college staff of our depa
            as some staff of the Institute of Medical Biophysics, who jointly address research topics.
            focused on the electrophysiology of visual perception.






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            * Equipment

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            • 16 VEP - TrueTrace (Deymed) - registration of visual evoked potentials, possibility of r
              movements

            • 64-channel EEG - TrueScan (Deymed) - mapping of brain activity with a sampling rate of u
            • HEP perimeter (Heidelberg Engineering) - computerised perimeter for flicker stimulus exa
            • OCT Spectralis (Heidelberg Engineering) - retinal examination with resolution of microme

            • EyELink 1000 plus (SR research) - eye movement registration device
            • NeuroConn DC stimulator Plus (neurocare group AG) - single channel device for non-invasi
              current stimulation

            • MagStim R30 (Magventure) - TMS device for non-invasive transcranial repetitive stimulati




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            * Achievements

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            2018, 2020 Marmor Award for Clinical Innovation in Visual Electrophysiology