4th Department of Internal Medicine – Haematology ****************************************************************************************** * ****************************************************************************************** IV. internal hematology clinic (IV. IHK) is one of the largest hematology departments in t Republic. It is a progressive and modernly equipped department providing the whole spectru blood diseases, including allogeneic hematopoietic cell transplantation and treatment with receptor T-lymphocytes (CART-cells). In addition to inpatient stations (including a haemat care unit and a transplant unit), outpatient clinics including specialised consulting room for haemostatic disorders dealing with bleeding and thrombotic conditions, the clinic is e modern separator centre offering highly specialised methods including LDL apheresis and re but not least, a highly important part of the clinic is the endocrinology unit providing c including the possibility of radioiodine treatment. The IV. IHK there are a number of prof focused not only on medical care, but also on scientific research tasks. The clinic regula top in the field of publication activities within the Hradec Králové University Hospital a Králové University Hospital. The department has been and is involved in a number of research projects as principal inve principal investigator, in particular AZV, for example "Efficacy and safety of tyrosine ki after two-step dose reduction in patients with chronic myeloid leukemia", "Cardiovascular flavonoid metabolites and the influence of metabolic risk factors", "Prognostic significan tumor DNA in Hodgkin's lymphoma", "Mapping the molecular-pathological mechanisms of hemato and thyroid cancer", Internexin-alpha in aggressive/rapid and slow growing clinically affu pituitary adenomas" and others. ****************************************************************************************** * Main research topics ****************************************************************************************** • Proteomics in multiple myeloma, new methods for paraprotein determination and minimal re • Investigation of cellular transporters and their inhibitors in relation to new drug resi leukemias • Evaluation of immunosuppression and modern prognostic and predictive markers in chronic leukemia ****************************************************************************************** * Scientific research groups ****************************************************************************************** Scientific and research activities are carried out within the individual professional grou (e.g. lymphoma / CLL group, myeloma group, acute leukaemia and transplantation group, sepa myelodysplastic and myeloproliferative diseases group, haemostasis disorders centre, endoc group). Members of the groups cooperate with laboratory staff from other departments of th Medicine and the Faculty of Medicine of Charles University (Institute of Clinical Immunolo Fingerland Institute of Pathology, Institute of Clinical Biochemistry and Diagnostics, Ins Clinical Microbiology, etc.). ****************************************************************************************** * Equipment ****************************************************************************************** • The Sysmex XN-3000 haematology analyser with integrated smear and stain automation and d morphology system. The system also enables the measurement of advanced new parameters su or COVID-19. • STAGO STA R Max3 and STA Compact Max3 coagulometers. Instruments measuring on both coagu optical principles. They enable a comprehensive assessment of haemostasis. • Instruments for assessing platelet function (aggregometers, PFA-100) • Miltenyi Biotech autoMACS Pro cell separator - device for magnetic separation of selecte cells using specific antibodies, e.g. multiple myeloma or acute leukaemia cells from per bone marrow. ****************************************************************************************** * Achievements ****************************************************************************************** • Based on the collaboration within the Czech Myeloma Group, the department has published prognostic score for elderly patients with multiple myeloma (Radocha J et al., Am J Hema • A prognostic score for patients with chronic lymphocytic leukaemia diagnosed at an early developed under the leadership of our department through collaboration across the Czech et al., Br J Haematol 2021) • Laboratory IV. IHK in collaboration with other departments of the Faculty of Medicine an Medicine of the Medical University of HK showed that the Intensive Care Infection Score uses parameters obtained from blood cell analyzers during blood counts, is elevated in p moderate and severe forms of COVID-19 in the early stages of the disease (Vrbacki F et a Public Health 2022) • Clinic staff have been awarded a number of prizes, such as the Přerov Prize of the Czech Angiology for the best publication in 2021 and the Cancer League Award for Publication i