Department of Infectious Diseases












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            The Department of Infectious Diseases is a supra-regional facility that provides outpatien

            care, including intensive care, to patients with infectious diseases from the Hradec Králo
            patients with selected infections from neighbouring regions. The department provides clien
            health care in accordance with current scientific knowledge, provides undergraduate and po

            education, including the development of scientific activities. Particular attention is pai
            arising from the changing spectrum of infectious diseases and the rational use of antibiot
            clinic has long-established specialized clinics: liver, CNS infections, zoonoses, parasiti

            borreliosis. An AIDS centre and a vaccination and travel medicine centre are operated at t
            These centres and the long-term follow-up of patients with selected diagnoses have a supra

            The clinic is involved in international multicentre studies.

            The department has long been involved in research topics (grants and scientific studies) i

            effectiveness, safety and tolerability of treatment of chronic viral hepatitis B and C, in
            therapy of the flu and on the field of vaccination.






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            * Main research topics
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            • Open label phase 2 study to assess the safety, tolerability and efficacy of chronic vira
              treatment, OCTOPUS-1
            • Multiclinical grant AZV 9302: Clinical phenotype of Sars-CoV-2 vaccinated persons hospit

              COVID-19 disease as a basis for optimization of national vaccination strategy and post-e
              prophylaxis






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            * Research groups
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            The research team is mainly involved in international studies, foreign and domestic grants
            by a fully certified medical platform and NLP.


            • The most stable group (3 physicians and the corresponding NLP) is the research team, whi
              working in the field of viral hepatitis treatment research for a long time
            • Ad hoc teams are formed to address other current research needs, currently mainly in the

              covid-19





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            * Achievements
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            • Publication output from ECDC grant in Euro Surveillance: Merdrignac L, Belghiti FA, Pand

              Murphy J, Fabianova K, et al. Incidence and severity of pertussis hospitalisations in in
              than one year in thirty-seven hospitals of six EU/EEA countries, results of PERTINENT se
              surveillance system, December 2015-December 2018. Euro Surveill.2020

            • Publication output in Q1 journal: Céline Boutry, Andrew Hastie, Javier Diez-Domingo, Jua
              Tinoco et al.: Zoster-049 Study Group, The Adjuvanted Recombinant Zoster Vaccine Confers
              Protection Against Herpes Zoster: Interim Results of an Extension Study of the Pivotal P

              Trials ZOE-50 and ZOE-70, Clinical Infectious Diseases, Volume 74, Issue 8, 15 April 202
              1467, https://doi.org/10.1093/cid/ciab629