The Fingerland Department of Pathology












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            The department was established in 1928 and provides a full range of necropsy, biopsy and c

            diagnostic services. The Institute includes laboratories for biopsy, cytology, immunohisto
            electron microscopy, in situ hybridization and molecular pathology. Special scientific and
            focus of the department: cardiovascular pathology, haematopathology, head and neck patholo

            stomatopathology, gynaecopathology, thyroid pathology, breast pathology, central nervous s
            neuroendocrine system pathology. The institute is a teaching centre of the Faculty of Medi
            University in Hradec Králové and teaches bachelor, master (general medicine and dentistry)

            study programmes (pathology) in Czech and English.






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            * Main research topics
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            • New predictive markers for solid malignancies and haemato-oncological diseases.
            • Etiopathogenesis of precancerous and malignant tumors of the head and neck and female ge
            • New differential diagnostic and predictive markers in central nervous system and pituita

              neuroendocrine tumors.





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            * Scientific research groups
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            • Group for research of predictive markers in cancer (prof. MUDr. Aleš Ryška, Ph.D. [ URL 

              is.cuni.cz/webapps/whois2/osoba/1024820499648708/?lang=cs"] ); focus on research of new 
              markers in breast cancer, lung cancer and colon cancer in order to improve the possibili
              personalized medicine

            • Head and Neck and Female Genital System Cancers Research Group (prof. MUDr. Jan Laco, Ph
              [ URL "https://is.cuni.cz/webapps/whois2/osoba/1678829875027853/?lang=cs"] );focus on re
              etiopathogenesis of sinonasal, pharyngeal and salivary gland cancers, focus on molecular

              characteristics of ovarian, uterine mucosa, cervix and vulva cancer; research on interac
              cancer and immune system
            • Central nervous system and pituitary and neuroendocrine tumours research group (MUDr. Ji

              [ URL "https://is.cuni.cz/webapps/whois2/osoba/1397825735308600/?lang=cs"] ); focus on r
              new differential diagnostic and prognostic immunohistochemical and molecular genetic mar
              tumours






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            * Equipment

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            • Multiparallel Sequencing System - NGS technology enables detection and multiple comparis
              point mutations (SNVs), deletions, insertions, copy number variations (CNVs) and structu

              used for comprehensive molecular profiling of solid tumors
            • Cyclers for real-time PCR - highly sensitive method for qualitative mutational analysis,
              targeted detection of variants in paraffin-fixed tumour tissue or in freely circulating 

              blood plasma
            • Tissue microarray- TMA-technology enables very efficient high-throughput pathology, wher
              is cut out from a donor tissue block under microscopic control and then transferred to a

              block. Expression profiles of up to several hundred samples can be monitored in a single
              with significant savings in reagents and time during readout






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            * Achievements
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            • 2022-2023 - prof. MUDr. Aleš Ryška, Ph.D. [ URL "https://is.cuni.cz/webapps/whois2/
              osoba/1024820499648708/?lang=cs"] , President of the European Society of Pathologists
            • 2022 - prof. MUDr. Jan Laco, Ph.D. [ URL "https://is.cuni.cz/webapps/whois2/osoba/167882

              lang=cs"] , became one of the co-authors of the 5th edition of the WHO classification of
              cancer


            The institute operates a biological material bank, which is involved in the Czech part of 
            distributed research infrastructure of pan-European importance - BBMRI (Biobanking and Bio
            Resources Research Infrastructure), which aims to create and operate a network of biologic

            for biomedical research. The biobank primarily holds native tumour tissue for future genom
            analysis for diagnostic, prognostic, predictive and research purposes.