Department of Pediatrics












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            Scientific and research activities together with curative and preventive care, undergradua

            postgraduate education represent one of the basic activities of the Department of Pediatri
            the department participate in scientific research projects within CU MED HK and FN HK and 
            other departments in the Czech Republic and abroad. The main areas of research of the depa

            neonatology, paediatric gastroenterology, paediatric endocrinology, paediatric nephrology,
            is also set up within other paediatric specialisations.







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            * Main research topics
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            • Diabetes mellitus and its impact on child development and health in a broader context

            • D-lactate in pediatric patients on home parenteral nutrition.
            • Composition of the GIT microbiome in preterm neonates in relation to perinatal pathologi


            1.Neonatology
              Composition of the GIT microbiome in preterm neonates in relation to perinatal and postn
              characteristics and its association with hemorrhagic and necrotizing enterocolitis. Proj

              Jan Malý, Ph.D. [ URL "https://is.cuni.cz/webapps/whois2/osoba/1699992706165286/?lang=cs
              Vitamin D metabolome and its association with the gut microbiome in a population of imma
              neonates. Project leader MUDr. Tomáš Matějek, Ph.D. [ URL "https://is.cuni.cz/webapps/wh

              osoba/1332283060140943/?lang=cs"]
            2.Paediatric gastroenterology
              D-lactate in pediatric patients on home parenteral nutrition.

              The project includes microbiome analysis and genetic analysis of D-lactate metabolism. D
              Pediatrics (MUDr. Jan Melek [ URL "https://is.cuni.cz/webapps/whois2/osoba/1489266737983
              in collaboration with theÚKBD (Alena Tichá, Ph.D.), the Department of Clinical Microbiol

              Rudolf Kukla, Ph.D. [ URL "https://is.cuni.cz/webapps/whois2/osoba/1712867201384575/?lan
              Department of Medical Genetics (Vladana Skutilová, M.D.).
            3.Paediatric endocrinology and diabetology

              Current projects are focused on the consequences of diabetes mellitus in the pediatric p
              Cognitive function in children with diabetes, especially executive function, (2) Diabete
              and its impact on the newborn and further child development, (3) Microcirculation in var

              associated with diabetes (diabetic ketoacidosis)
            4.Dětská nefrologie
              Epidemiological and prognostic factors in selected nephropathies and congenital kidney d

              leader: doc. MUDr.Sylva Skálová, Ph.D. [ URL "https://is.cuni.cz/webapps/whois2/osoba/17
              lang=cs"]






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            * Cooperation
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            • Department of Pediatrics, FNM and 2st LF UK in Motol, Prague
            • Department of Pediatrics, Faculty of Health Studies, J.E. Purkyně University Ústí nad La






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            * International Cooperation

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            • Prof. E. Lopriore, Leiden Univesity Medical Center
            • N. Houben, Leiden Univesity Medical Center v rámci sítě European Rare Kidney Diseases Re

              (Prof. Franz Schaefer, Heidelberg)







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            * Important achievements
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            • 2018 Tereza Vitvarová, David Neumann, Radka Šimáková, Jan Kremláček, "Neurophysiological
              for a Compensatory Activity during a Simple Oddball Task in Adolescents with Type 1 Diab
              Mellitus", Journal of Diabetes Research, vol. 2018, Article ID 8105407, 9 pages, 2018. h

              doi.org/10.1155/2018/8105407 IF 4,3
            • 2023 Krausova V, Neumann D, Kraus J, Dostalova V, Dostal P. Sublingual microcirculation 
              pediatric population using the sidestream dark-field imaging method. Clin Hemorheol Micr

              2023;85(2):163-171. doi: 10.3233/CH-231851. PMID: 37599527. IF 2,1
            • 2024 Krausova V, Neumann D, Skvor J, Dostal P. Changes of Sublingual Microcirculation du
              Treatment of Severe Diabetic Ketoacidosis. J Clin Med. 2024 Mar 14;13(6):1655. doi: 10.3

              PMID: 38541881; PMCID: PMC10971367. IF 3,9

            The department is engaged in a number of other research projects in which it participates 

            Republic and in cooperation with foreign countries. Current projects include research on t
            metabolome and its association with the gut microbiome in the population of immature newbo
            Matějek, Ph.D.) and research on diabetes in pregnancy and its impact on the newborn and fu

            development (MUDr. Kateřina Krylová, Ph.D.). The department is involved in projects relate
            diseases in the Czech Republic and abroad (doc. MUDr. Sylva Skálová, Ph.D.)