Department of Clinical Microbiology












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            The department processes more than 120,000 clinical samples annually for the detection of 

            mycotic, viral and parasitic agents. The Department of Clinical Microbiology is part of a 
            institutes focused on national and international surveillance of antibiotic resistance of 
            bacterial pathogens, and also operates the National Reference Laboratory for Cytomegalovir

            scientific interests of the Institute are focused in several directions. One of them is in
            by typical and atypical mycobacteria, possible modes of transmission from the environment 
            of new antituberculosis drugs. Another area is the role of the microbiome in the gastroint

            urogenital tract and its influence on the development of serious clinical diseases. An imp
            direction is the role of the microbiota in pregnancy complications such as premature amnio

            and preterm birth. Traditionally, the pathogenesis of infections with herpes viruses as we
            current viral agents (SARS-CoV-2) is also being investigated in the context of the referen
            Finally, the analysis of the causative agents of serious mycotic infections, especially in

            and in immunosuppressed patients, as well as the testing of new antifungal agents is being





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            * Main research topics
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            • The role of organ microbiomes in the pathogenesis of serious diseases

            • Resistance of microorganisms and the development of new antimicrobial agents
            • Mechanisms of viral disease pathogenesis






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            * Scientific research groups
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            • The role of the microbiome in the pathogenesis of GIT, urogenital tract and immunosuppre
            • Role of microbial flora in intra-amniotic complications of preterm amniotic fluid leakag
              birth

            • Mycobacterial infections, mycobacterial resistance, importance of atypical mycobacteria 
              environment for humans
            • Study of the mechanisms of pathogenesis of viral diseases caused mainly by DNA viruses a

            • Development and testing of new antimycobacterial agents and antifungals





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            * Department activities
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            • AZV MZ ČR No. NU21J-07-00058 Quantification of intra-amniotic inflammation in premature 

              leakage on the background of global proteomic response
            • VES MZ COVID (NU22-A106) - Clinical phenotype of SARS_CoV-2 vaccinated persons hospitali
              disease as a basis for optimization of national vaccination strategy and post-exposure p

            • NW24-05-00539 Development of novel compounds as options to address the adverse epidemiol
              fungal infections;
            • NU20-09-00114 Non-tuberculous mycobacteria in the Czech Republic: current risks and impr

            • AZV NW24-07-00129 (Pato)physiological role of the endocannabinoid system in pregnancy ma
              preterm birth