Mazanek, Pavel
Poslední změna: 19.09. 2016

Department of Pathological Physiology

In the curriculum of General Medicine at our Faculty, pathophysiology comprises 157 instruction hours in the 3rd study year before students move on to clinical coursework in the fourth year. Pathophysiology is quite unique as it does not have to introduce many new facts but has to teach (force!) the students to integrate their theoretical knowledge to understand the origins (etiology) and development (pathogenesis) of diseases so that those diseases (or their complications) may be prevented or adequately treated. In our instruction a comprehensive (global, holistic) approach is maximally applied to help students understand the basics of the disease. Such an approach is often mistakenly considered to be the exclusive domain of alternative / complementary medicine. Pathophysiology is a field that can be very unpleasant for students who are accustomed mainly to memorizing facts. However, it is always better for the patient if the doctor does not mechanically apply the “best clinical practices“ (guidelines). During the final oral exam, students are evaluated not only in terms of their knowledge but also in terms of how trustworthy they would seem to be as doctors.

Electrophysiology of vision

The electrophysiology laboratory currently represents the main aim of the department’s research and involves pursuing new variants of visual evoked potentials and cognitive brain potentials, especially during different variants of motion stimulation, with testing of their new diagnostic applications. The importance of the laboratory in Czech clinical neurophysiology is documented by the fact that Assoc. Prof. Kremlácek is the president of the Neurophysiological Society of the Czech Medical Association of J.E. Purkyne.


Since 1997, research in immunotoxicology has been the responsibility of Associate Professor Lenka Borská, M.D., Ph.D. It takes place in cooperation with a number of theoretical and clinical departments of the Charles University Faculty of Medicine and University Hospital and also foreign institutions (Faculté de Médecine – Université de Montréal, National Institute of Occupational Health, Oslo). In the last ten years, research has focused specifically on assessing the benefits and risks arising from the Goeckerman method of psoriasis treatment (pharmaceutical coal tar with a high content of polycyclic aromatic hydrocarbons + UV radiation). This research includes tests such as genotoxicity, oxidative stress, epigenetic analysis (methylation of the p53 protein), and protective capacity (25-hydroxes of D vitamin). Furthermore, we investigate the pathophysiology of inflammation in patients suffering from psoriasis and associated comorbidities, focusing on the risks arising from metabolic syndrome.