Mazanek, Pavel
Poslední změna: 19.09. 2016

Department of Pharmacology

We have gradually created and continuously upgrade study texts available to our students at the webpages of our department, and have introduced three supporting computer applications. The first such applications were interactive presentations purchased from the companies Pharmac-a-logy and Pharmatutor. They provide students illustrative presentations of indivi dual problems in the field. This has been closely related with the usage of computer simulations which have gradually replaced demanding experiments on animals or on isolated organs and help demonstrate the mechanisms of the effect of the chosen drugs or their pharmacokinetics. The third supporting application are case reports from clinical practice which were prepared in cooperation with specialists from individual clinics and presented in the form of interactive web applications describing solutions to specific pharmaco-therapeutic situations. All the created teaching materials are at present available on our faculty´s secure server – moodle.lfhk.cuni.cz.

Cardiovascular pharmacology

We study cardiovascular toxicity of antineoplastic drugs with the potential of pharmacologic cardioprotection. While in the past we have focused on clinically significant cardiotoxicity of anthracycline antineoplastics (for example, doxorubicin or daunorubicin), recently we have chosen to investigate specific biologically-aimed drugs (for example, Sunitinib or inhibitors of proteasome). We are focusing mainly on in vivo research into the chronic forms of cardiovascular toxicity of these abovementioned drugs in laboratory animals (rabbits, rats and mice).

Research in clinical pharmacology

We focus on the usage of individual and population modelling of pharmacokinetics, pharmacodynamics, and bio-indicators of therapeutic and toxic effects of drugs for individualization in pharmacotherapy. In the field of clinical pharmacology, we have been cooperating for 15 years with the Department of Dermatology and Venereology at the University Hospital Hradec Králové on the topic of methotrexate in curing focal psoriasis. Other areas of clinical pharmacology research are the treatment of idiopathic juvenile arthritis, Crohn’s disease, and the usage of non-invasive methods of examining bioindicators in respiratory tract disease with inflammation.