Mazanek, Pavel
Poslední změna: 16.09. 2016

Department of Physiology

The traditional approach to practical physiology teaching based upon animal experiments is already a thing of the past. Ethic, legislative, economical as well as scientific reasons have caused a significant limitation to experiments on animal mo dels not only in our country but worldwide. We either use alternative approaches when measuring, observing and carrying out non-invasive experiments on human volunteers, which means on the students themselves, or other alternatives represented by computer programs that simulate chosen physiological processes.

The team of experimental hepatology

Under the leadership of Professor Cervinková, the team has the long term goal of researching toxic liver injury, including mechanisms of the impact of model hepatotoxins and substances with a possible hepatoprotective effect. Furthermore, we research liver regeneration induced by partial hepatectomy or toxic liver damage, sensitivity of the liver to hepatotoxic substances and the regenerative response of the liver when affected by a nonalcoholic fatty liver disease (NAFLD, NASH), extrahepatic cholestasis induced by ligation of d. choledochus and the further possibility of affecting liver damage (for example by statins).

Metabolism of proteins and amino acids

This research is led by Professor Holecek and is focused on experimental studies into the metabolism of amino acids in relation to the pathogenesis of proteocatabolism in diseases complicated by cachexia (acute and chronic conditions of the liver, renal insufficiency, sepsis). A further focus of the research is the side effects of nutrition supplements recommended to induce positive protein balance in costal muscles and the importance of changes of aminoacidemia in the pathogenesis of liver encephalopathy. In addition, Professor Holecek’s research interests for many years have focused on amino acids with branched-chains and glutamine.

Experimental cardiology

Associate Professor Adamcová is a leading person in this field in our department. Her work is closely linked with the research of the cardiology group from the Department of Pharmacology. Her present research activities are focused on the study of the cardiotoxicity of antineoplastic substances, namely on the use of cardiac troponins T and I in the evaluation of the cardio- toxic and cardio-protective effects of new drugs, and on predicting the development of anthracycline cardiomyopathy with the help of biomarkers of cardiac damage. Further research involves the problem of remodelling the myocardium under various pathological conditions and the possibility of influencing pharmacologically hypertrophy and fibrosis.